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Endogenous sex hormones are well-established risk factors for breast cancer; the contribution of specific oestrogen metabolites (EMs) and/or ratios of specific EMs is less clear. We have previously identified a CYP3A7*1C allele that is associated with lower urinary oestrone (E 1 ) levels in premenopausal women. The purpose of this analysis was to determine whether this allele was associated with specific pathway EMs.

CYP3A7*1C allele is associated with reduced levels of 2-hydroxylation pathway oestrogen metabolites