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The study by Nettersheim et al (2016a) is a highly interesting work, revealing the potential of PRAME (preferentially expressed antigen of melanoma) for diagnostic discrimination of human type II germ cell cancers. Moreover, the presented data is incorporated into a model placing PRAME into a decisive position for the cell fate choice with regard to pluripotency or differentiation in primordial germ cells and seminomas.

PRAME as diagnostic marker and as regulator for cell fate decisions in germ cell cancers