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Selecting patients with 'sufficient life expectancy' for Phase I oncology trials remains challenging. The Royal Marsden Hospital Score (RMS) previously identified high-risk patients as those with ≥ 2 of the following: albumin &lt;35 g l(-1); LDH &gt; upper limit of normal; &gt;2 metastatic sites. This study developed an alternative prognostic model, and compared its performance with that of the RMS.

Prediction of early death among patients enrolled in phase I trials: development and validation of a new model based on platelet count and albumin