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The variable penetrance of breast cancer in BRCA1/2 mutation carriers suggests that other genetic or environmental factors modify breast cancer risk. Two genes of special interest are prohibitin (PHB) and methylene-tetrahydrofolate reductase (MTHFR), both of which are important either directly or indirectly in maintaining genomic integrity.

british journal of cancer

Association of PHB 1630 C&gt;T and MTHFR 677 C&gt;T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study