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Tumour necrosis factor-alpha (TNF-alpha) reduced the interstitial fluid pressure (IFP) to 54-64% (P &lt; 0.05) and the mean arterial blood pressure (MABP) to 70% (P &lt; 0.01) of control values after 5 h in three human melanoma tumour lines transplanted to nude mice.

Reduction of interstitial fluid pressure after TNF-alpha treatment of three human melanoma xenografts