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We have used this polymer hydrogel system in an attempt to improve i.p. chemotherapy by implantation into the peritoneal cavity. This system releases cisplatin over several hours and is co-administered with a large volume of NaCl comparable with that normally used in i.p. cisplatin treatment. We report here out studies using this slow release system for i.p. chemotherapy to investigate antitumour response for cancers restricted to peritoneal cavity in relation to the induced nephrotoxicity

british journal of cancer

Antitumour response and nephrotoxicity following intraperitoneal administration of a slow release formulation of cisplatin to rats bearing cancers restricted to the peritoneal cavity