English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Inhibitors of natural killer (NK) cell activity in cell-culture supernatants, believed to be antigens recognized by NK cells, were defined by their ability to inhibit NK cells in 51Cr-release cytotoxic assays. Supernatants from cultures of melanoma cells and Chang cells were used as the source of the antigen. Partial characterization by a number of sequential separation procedures suggested that the antigens were glycoproteins in the size range 120-140,000 daltons which had affinity for both concanavalin A and wheat germ lectin. Inhibitory activity was destroyed by trypsin digestion, but was resistant to neuraminidase and a number of physical procedures. Addition of supernatants to NK assays against a number of different target cells indicated that inhibition was restricted to certain target cells. This indicated that the inhibition of NK cells was not non-specific, and that the antigens were not expressed on all target cells. These studies provide a basis for further analysis of antigens recognized by NK cells, and allow investigation of their role in vivo in tumour-bearing hosts.

Characterization of antigens recognized by natural killer cells in cell-culture supernatants