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An in vivo-in vitro implantation model has been used to investigate further the early stages of chemically induced s.c. neoplasia in the mouse. Cell cultures of implant-site tissues from control and 3,4-benzpyrene (BP)-treated animals were found to mirror the in vivo tissue reactions occurring at the time of explantation (Westwood et al., 1979). Cells were classified into 6 different types. The most abundant cell type in later control cultures was of a typical fibroblast morphology. However, a suppression of growth of fibroblast-like cells occurred when BP-treated tissues were explanted, and a selection of growth in favour of the large polygonal Type 5 cells was observed. When grown from BP-treated tissues Type 5 cells were found to be capable of growth in a semi-solid agar medium. Quantitative studies showed that cells capable of growth in agar reached a peak about 4 weeks after implantation, followed by a decline in numbers until the formation of tumours. This observation may result from the parameters regulating the development of chemically induced neoplasia in the subcutis.

Analysis of cell cultures of 3,4-benzpyrene-treated subcutis and subsequent growth in semi-solid medium