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HOST CELLS infiltrating tumours have been observed for many vears, but have recently become the subject of increasing interest (rev. by Haskill et al., 1978). ITarious types of lymphoid cells aiid macrophages have been separated from tumours, and have been shown to have anti-tumour effects in vitro (Holden et al., 1976; Gillespie & Russell, 1.978; ffaskill et al., 1978). Hitherto, however, there has been little evidence of the relevance of these in vitro activities to the control of tumour growth in vivo. We report here experiments showing that lymphoid cells from within a progressively growing rat fibrosarcoma can prevent tumour growth when injected in admixture with sarcoma cells in a Winn assay. These studies were performed using a 3-methyleholanthrene-induced sarcoma (Mc7) transplanted s.c. in syngeneic WAB/ Not rats. This tumour has previously been shown to be immunogeiiic (Baldwin et al., 1971), immunized rats being capable of rejecting 2 x 1.06 viable tumour cells, whilst the minimum inoculum for growth in unimmunized rats is 3 x 105 cells. In the experiments described here, tumours used as a source of lymphoid cells were taken 10 days after s.c. injection of 106 tumour cells into normal syngeneic rats. Tumours

Tumour-derived lymphoid cells prevent tumour growth in Winn assays