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THERE are well documented studies which show that host factors in the mouse are important determinants of tumour radiosensitivity (Cohen & Cohen, 1956; Haddow & Alexander, 1964; Powers et al., 1967; Maruyama, 1967; Suit & Kastelan, 1970). However, the biological mechanism which effects this improved response is not clearly understood (Song & Levitt, 1975; Johnson, 1978). As part of an investigation of the interaction of X-rays and immune cytotoxicity in tumour control, an experimental mouse model system (Porteous et al., 1976) has been used in which quantitative antitumour immunity was raised in prospective recipients of tumour-cell suspensions exposed to varying doses of X-rays in vitro before injection. Here we report findings which indicate that, whilst X-rays kill a proportion of cells, induced immunity deals with a fixed number dependent upon the immune status of the host, and that X-rays and anti-tumour immunity do not act synergistically in tumour-cell killing. The tumour used was the ascites sarcoma BP8, and experiments were performed between weekly Passages 268 and 315 of the tumour in inbred 10-12-weekold DMC/Ps mice. Anti-tumour immunity was assessed by a terminal dilution method (Hewitt & Wilson, 1959) to give TD50 (the number of viable tumour cells required to trasmit the tumour and give Accepted 15 January 1979

Tumour-cell killing by X-rays and immunity quantitated in a mouse model system