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STUDIES on the neoplastic potential of substituted hydrazines have been under way in this laboratory since 1968. These investigations are carried out in randomly bred Swiss albino mice and Syrian hamsters, and chemicals are administered at the maximum tolerated dose continuously in drinking water for life. To date, 24 hydrazines are known to produce tumours in laboratory animals (Bianci-well over a hundred hydrazine derivatives are in the environment and many of these coinpounds are widely used in industry, agriculture and medicine. It has recently been pointed out that 5 chemicals of this class occur naturally, in tobacco and in some edible mushrooms. Two were previously shown to induce tumours in animals, while studies with the other 3 compounds are in progress (Toth, 1975). The present work records the tumouri-genicity of allylhydrazine HCI given to Swiss mice daily in drinking water for life. Swiss albino mice from the colony randomly bred by us since 1951 were used. They were housed in plastic cages with granular cellulose bedding, separated according to sex in groups of ten, and given Wayne Lab Blox diet in regular pellets (Allied Mills, Inc., Chicago, Illinois) and tap water or the test solution ad libitum as described below. The chemical used was allyhydrazine puirity: 9800 by gas chromatography, synthesized in this laboratory. The 0.0125% solution which was used for the chronic experiment was analysed by gas chromatography after 48 h standing and found to contain more than 9700 of the original compound. Allylhydrazine oxalate was synthesized as follows: over a period of 1X5 h, 36 g of allylbromide was added to a vigorously stirred solution of 150 g of hydrazine hydrate maintained at 50°C. After being stirred for 2 h the solution was continuously extracted withethyl ether for 20 h. The ether was removed by distillation and the residue poured into 35 g of oxalic acid dissolved in one litre of 950o ethanol. The resulting oxalate salt was re-crystallized from ethanol, m.p. 160-161TC.

Tumour induction study with allylhydrazine HCl in swiss mice