English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

WE RECENTLY noted that the inherent incidence of spontaneous lymphomata in the AKR mouse strain was markedly reduced by ovum fusion to the CBA/HT6T6 strain (Barnes, Tuffrey and Kingman, 1972a). Whereas lymphomata were invariable in the AKR strain, tumours were seen only in a third of ovum fusionderived AKR +-+ CBA/H-T6T6 tetraparental chimaeras (Barnes, Tuffrey and Ford, 1973). The tumour resistance of these chimaeras was particularly surprising since, in spite of roughly balanced coat colour composition and distribution of the gametes, cytogenetic analysis of the peripheral blood samples showed an overwhelming predominance (average >95%) of lymphoma-prone AKR lymphoid cells (Tuffrey et al., 1973). This predominance of AKR cells was not only seen in the peripheral blood, but was also noted in analysis of both the lymphomyeloid complex and the somatic tissues of all these chimaeras (Ford et al., unpublished). In spite of this, the AKR associated lymphomata appeared to have been in some way inhibited by relatively few CBA cells present in the chimaeras. One possible argument against this view was the possibility of maternal influence. After fusion of the AKR and CBA morulae, which had been cultured in vitro to the blastocyst stage, the embryo was then transplanted into a pseudopregnant recipient. In the case of the AKR <-* CBA/HT6T6 chimaeras, this was invariably a CBA/I-T6T6 recipient which was also Accepted 8 February 1974

Lymphoma susceptibility of the AKR mouse strain acquired before the stage of implantation