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INTRAVENOUS injection of bacillus Calmette-Guerin (B.C.G.) organisms suppresses growth of artificial pulmonary metastases of rat sarcomata, produced by intravenous injection of tumour cells (Baldwin and Pimm, 1973a). In addition, spontaneous pulmonary metastases, appearing after surgical removal of subcutaneous growths of a transplanted rat epithelioma, are restricted by intravenously administered B.C.G. (Baldwin and Pimm, 1973b). This type of growth suppression is probably a reflection of a B.C.G. mediatedgranulomatous response atthe site oftumour metastasis following B.C.G. entry into lung tissue and may be comparable with the restriction of tumour growth when cells are injected subcutaneously or intradermally in contact with B.C.G. (Baldwin and Pimm, 1971, 1973c; Bartlett, Zbar and Rapp, 1972; Zbar, Bernstein and Rapp 1971). So far, B.C.G. treatment of pulmonary metastasis has been evaluated with transplanted animal tumours; the objective of the present experimental studies was to assess the influence of intravenously administered B.C.G. on the development of metastases in animals bearing primary tumours, since this approximates more closely to the clinical situation. In these experiments rats with primary hepatomata, induced by oral administration of 4-dimethylaminoazobenzene, have been examined for pulmonary metastases and the influence of intravenously administered B.C.G. on their development studied.

B.C.G. suppression of pulmonary metastases from primary rat hepatomata