English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Open

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

2796), the other a renal adenocarcinoma. The dose response for total tumour incidence is a probit curve. Several workers have demonstrated acute and chronic effect;s in rats suckled by mothers treated during nursing, with toxic and carcinogenic substances such as pyrrolizidine alkaloids, cycasin, bracken etc., but no information was available with regard to the effects of diethylnitrosamine. We administered this substance to 3 female rats nursing their young. One mother given 7 doses died after 9 months and had a kidney tumour; nasal and other tumours started to appear among her offspring from the 10th month of life. Recently, Mohr et al. reported nasal and respiratory tract tumours in golden hamsters, among the offspring and mothers treated with diethyl-nitrosamine during nursing. Besides the parent nitrosamine, milk may contain in addition some of its biologically active metabolites. N-ethyl-N-nitrosoacet-aldehyde has been suggested as one of the possible active intermediates in the carcinogenic action of diethylnitrosamine. Carcinogenesis by some secondary N-nitrosamines may arise (Magee and Barnes, Adv. Cancer Res., 1967, 10, 163) from their alkylating action after metabolic oxidation of the a-carbon atom and subsequent decomposition to a diazo derivative (equation). The validity of this

Potential alkylating agents from the oxidation of carcinogenic cyclic n-nitrosamines