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Electron-microscopic examination of an oat-cell carcinoma associated with the ectopic ACTH syndrome demonstrated characteristic cytoplasmic granules of 60-240 nm. diameter, consisting of a dense central core separated by a clear halo from an outer investing membrane. Comparison with previously examined non-secretory oat-cell carcinomas showed the granules to be more numerous in the present case. They are considered to represent secretory activity in the tumour.

Fine Structure of an Oat Cell Carcinoma of the Lung Associated with Ectopic ACTH Syndrome