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LACTATE dehydrogenase (E.C. 1. 1. 27) has been extensively investigated (Winer and Schwert, 1957) as the catalyst of a reaction which is a control point in glycolysis. It is ubiquitously distributed in animal tissues (Damm et al., 1966), with a high molecular-population in muscle tissue. The enzyme has been studied in several laboratories relative to the alteration of its level of activity in a number of clinical abnormalities including malignancies (Ono, 1966). The basis of the elevation of lactate dehydrogenase activity in tumors as compared with the homologous tissues remains only incompletely explained. Goldman, Kaplan and Hall (1964) have referred to changes of LDH activity as part of a physiological phenomenon common with the general changes in the glycolytic rate first shown by Warburg (1930, 1956) to be associated with some neoplasia. Investigators have referred the lactate dehydrogenase system to cancer because the alteration of activity-level in the tumor is thought to represent a potentially exploitable difference between malignant and normal growth. It has been studied too, because the LDH system is measurable in serum and this, if it reflects tumor development, is a site for diagnostic observation. In addition, LDH exists in several forms (Markert and Moller, 1959). The isozymes lend promise of providing a higher-resolution diagnostic technique than does the measurement of the summation of all LDH-catalysis. It has been reported (Ono, 1966) that in tumor tissue there is, as compared with homologous tissue, a shift in the isozyme activity, particularly involving LDH bands IV and V. The present study is oriented toward an evaluation of the contribution of the several isozymes to the overall lactate dehydrogenase pattern in breast tumor tissue. Tumor activity has been compared in our study with lactating breast tissue isolated from animals of the same strain. These tumors hold a special interest because the carcinogen 3 : 2'-dimethyl-4-amino biphenyl appears to induce tumors in the Wistar rat with the same statistical distribution seen in certain human populations.

Lactate dehydrogenase isozymes of 3-2'-dimethyl-4-amino biphenyl-induced breast carcinoma.