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MALIGNANT melanoma is a disease of antiquity, as shown by the discovery of melanotic deposits in the bones of pre-columbian Inca mummies (Urtega and Pack, 1966). Malignant melanoma is a rare disease. The incidence in South Wales is of the order of 1V6 per 100,000 for females, and 1*4 per 100,000 for males (Cancer Registration 1960-63). This incidence is similar to the American figure of 1*7 per 100,000 (Beerman et al., 1955) and much lower than the 14-3 per 100,000 quoted for Australia (Davis and Herron, 1966). This paper describes the clinical features and value of treatment, measured by 5-year survival experience and rate of recurrence, for a series of 111 patients seen in South Wales between the years 1941 and 1961. All of these patients were Caucasians. In 89, adequate pathological material was available and the clinico-pathological correlation is reported in the following paper (Williams et al., 1968). The clinical features examined were: sex, age, size, site, palpable regional nodes, pre-existing lesion, duration of symptoms, and the method of biopsy. All the survivors have been followed by interview and by clinical examination, and only those alive on the 5th (or later) anniversary of their treatment have been included in the survival tables. Survival rates have been calculated from the time of treatment of the primary disease, and not from the onset of the disease as others have done (Mundth et al., 1965). Though no distinction has been made between deaths from melanoma and deaths from other causes in the 5-year period, 69 were attributed to melanoma and 4 to other causes.

Malignant melanoma of the skin: prognostic value of clinical features and the role of treatment in 111 cases