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IN recent work in this laboratory it was shown that an extract of flue-cured cigarette tobacco leaf (WTE) as well as cigarette smoke condensate (WCT) exhibit tumor-promoting activity (Van Duuren et al., 1966). In these experiments a single dose of 7,12-dimethylbenz[a]anthracene (DMBA) was applied on mouse skin as initiator followed by repeated skin application of the promoting agents. While this procedure proved satisfactory for bioassay of a number of fractions and subfractions derived from tobacco leaf and tars, it was desirable also to explore systemic treatment with several initiating agents followed by skin application of the promoting agents. The present report describes the bioassay of several promoting agents with DMBA, benzo[a]pyrene (BP) and urethane as initiators. The initiators were given by subcutaneous and intraperitoneal injection in mice; the promoting agents were applied on skin. The results of these experiments are compared with our earlier results, in which both the initiator and promoter were applied on mouse skin (Van Duuren and Orris, 1965; Van Duuren et al., 1966).

The tumor-promoting activity of tobacco leaf extract and whole cigarette tar.