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1. Mice of two different strains (CBA and Herston white) failed to develop marked resistance to Ehrlich ascites tumour when immunized with iodoacetatetreated tumour cells, a procedure reported by others to be effective in protecting A-jax mice. 2. No circulating anti-tumour antibodies could be detected in the sera of the immunized mice, by a variety of techniques. 3. Delayed-type hypersensitivity to disrupted tumour cells was present in the immunized mice to a highly significant degree; however, this was not correlated with resistance to challenge with live tumour. 4. The possible reasons for the above observations are discussed.

Immune responses of mice to iodoacetate-treated Ehrlich ascites tumour cells.