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VOLUMINOUS literature is available on biochemical differences between malignant and non-malignant tissue, yet, precise biochemical characterisation of carcinogenesis of tissue is still a challenge to the biochemists at large. In recent years a number of biochemical studies on induced carcinogenesis of liver have been reported (Weber, Banerjee and Morris, 1961). However, literature on spontaneous carcinogenesis of any other tissue (including mammary tissue) is very scanty. The importance of experimental work on mammary carcinogenesis in general, and of systematic biochemical studies of the events before development of breast cancer in particular, need not be emphasised. Extensive biological studies on sequential histological development in mammary tumorigenesis have been reported from this laboratory (Ranadive, 1959) and abroad (Severi, 1958). The present authors have been interested in mammary carcinogenesis to study metabolic changes associated with malignant transformation and correlation of significant biochemical changes concurrent with the formation of precancerous hyperplastic nodules in the breast tissue. The present paper reports salient observations on metabolic alterations taking place in the breast tissue of mice from young adult stage of 4 months (when the mammary tissue shows normal histology) till the development of tumour in two strains of mice susceptible to breast cancer. For this purpose metabolic parameters of growth such as levels of riboand deoxyribonucleic acids, activities of ribonuclease (RNAase), adenosine-triphosphatase (ATPase) and acid and alkaline phosphatases were measured. Mammary glands of 4, 6, 8 and 10 months old virgin mice of two susceptible strains namely C3H (Jax) and I.C.R.C. were used for the experimental purpose. The latter strain, i.e. I.C.R.C. strain, is a newly developed inbred line of albino mouse and is highly susceptible to breast cancer (Ranadive and Kanekar, 1963). Virgin mice of corresponding age groups of C57 (Black) strain resistant to breast cancer were used for comparison.

Studies on sequential metabolic alterations in spontaneous mammary carcinogenesis.