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FOLLOWING the basic investigations of Huggins, Grand and Brillantes (1961), Huggins, Briziarelli and Sutton (1959) and Dao (1964) it is readily possible to induce mammary cancers in female Sprague-Dawley rats by administration of 3-methylcholanthrene or 7,12-dimethylbenzanthracene (DMBA), thus allowing the behaviour of these tumours to be studied under various conditions. As has been established particularly by Huggins, Grand and Brillantes (1961), and Furth (1961), the growth of these tumours depends on hormone state in the organism of the experimental animals, and may be reduced by male hormones (testosterone) or stimulated by female hormones (oestrogens, progesterone). Dao (1964) showed that mammary cancers can also be induced in rats by oestrogens alone so that a carcinogenic effect of female hormones cannot be excluded. The application of carcinogenic hydrocarbons mentioned is very frequently accompanied by acute toxic phenomena and leads in many cases to the death of the animals. Only when quite definite dose-time-relationships are noticed will these toxic effects be minimized. The purpose of our own studies was to check the possible existence of dose-effect-relations for testosterone in influencing the growth of DMBA-induced mammary cancer in rats by this androgen. The development of tumours following DMBA treatment has been noted and the growth rates of tumours which formed at different times have been compared with one another.

Growth and therapy of mammary tumours induced by 7,12-dimethylbenzanthracene in rats.