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IT has previouslv beeii suggested that the oncolytic reactioii that occurs wheii Ehrlich ascites carcinoma cells are brought into coiitact with fresh humaii serum is due to the complement in the serum acting on the cells that have been sensitised in vivo (Hartveit, I965). The cells, in this case, have beeii sensitised as a result of a homograft reaction oii the part of the genetically iiicompatible host. The Bergen A4 ascites carcinoma (Hartveit, 1964), on the other hand, arose in a strain A/Sii mouse kept at this Institute aiid is kept bv serial transplantatioii in geiietically compatible mice, i.e. mice that are compatible with the host of origin. So in this case the tumour cells caniiot become sei-isitised as the res-Litt of a homograft reaction. If thev show signs of sensitisation some other meeliaiiism must be at work. Previous studies oii the oiicolytic reactioii reported in tiie literature (Hartveit, 1965a) have, with one exception (Willheim and Ivy, 1959), used either transplanted mouse tumours growing as homografts or cells in tissue culture (Bolande, 1960). In iio case has a tumour transplanted to a geiieticallv compatible host beeii used. The following experiments were therefore carried out on such a tumour, the Bergen A4 ascites carcinoma, to see whether the cells were seiisitised

The Lytic Action of Fresh Human Serum on Bergen A4 Ascites Carcinoma Cells