English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

THE reduction of Ring A of adrenal steroids by the A4-steroid hydrogenases of liver has been shown in man (Peterson, Wyngaarden, Guerra, Brodie and Bunim, 1958) and in the rat (Glenister and Yates, 1961) to be the rate-controlling step in the inactivation of corticosteroids. Urquhart, Yates and Herbst (1959) have further shown that there is a close correlation between adrenal size and the level of this enzyme system in the liver. Thus under experimental conditions where a rise in the activity of this enzyme was induced, for example by treatment with thyroxine (Yates, Urquhart and Herbst, 1958) or castration of male rats (Yates, Herbst and Urquhart, 1958), there was an increase in adrenal weight; conditions which produced a reduction in enzymic activity, such as partial hepatectomy (Urquhart et al., 1959), caused adrenal atrophy. Administration of corticotrophin or cortical hormones, on the other hand, did not increase the inactivating capacity of the liver (Urquhart et al., 1959). These authors therefore concluded that it is the level of hepatic A4-steroid hydrogenase activity which determines adrenal size rather than the reverse. Since adrenal hypertrophy is a common feature of tumour-bearing animals (Begg, 1958) the present study was undertaken to determine whether the presence of a growing tumour affected the rate of hepatic reduction of Ring A of adrenal steroids.

The Effect of the Walker 256 Carcinoma on Hepatic Δ4-Steroid Hydrogenase Activity