English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

IT has been shown previously (Hartveit, 1961) that the adult mice used at this Institute show either a short survival time and a very haemorrhagic tumour or a long survival time and a relatively asanguinous tumour, following the intraperitoneal injection of Ehrlich's ascites carcinoma. This negative correlation between the survival time and the blood content of the tumour is not dependent on the sex or weight of the mouse. As this tumour is said to grow progressively in almost all strains of mice (Karnofsky, 1953) it was decided to investigate the causeof this difference in survival time and blood content found in our mice. In 1934 Apitz tested the theory that haemorrhage into the solid Ehrlich carcinoma might be due to anaphylaxis, but he failed to produce haemorrhage by this means. He also failed to produce haemorrhage as the result of treatment withi histamine. Later Barrett (1942) investigated the relationship between anaphylaxis and sarcoma 37. He was able to show that the anaphylactic shock produced in previously sensitized mice in response to horse serum was accompanied by haemorrhage into actively growing transplants of this tumour. The reaction did not occur in non-sensitized animals. He also produced haemorrhage into the tumour in strain A mice in response to intraperitoneal histamine. The haemorrhagic reaction was not confined to the tumour but was also present, to a lesser extent, in the stomach and small intestine. Barrett's experiment suggests that haemorrhage into a tumour may be the result of the combination of a foreign antigen with antibody present in the tumour. The mice used in this Institute are heterozygous and also of different genetic make-up from Ehrlich's ascites carcinoma. It was thought that their differences in reaction to the tumour might represent different degrees of genetic difference, and thus different degrees of resistance to the homotransplant. Ludford (1931) and Andervont (1936) have shown that resistance to tumour transplants can be abrogated by vital staining with trypan blue. More recentlv many authors (reviewed by Toolan, 1953) have shown that it is possible for homotransplants to grow in animals treated with cortisone. The following experimenit was planned in an attempt to reduce the resistance of inice to a tumour homotransplant (i.e. intraperitoneal Ehrlich's ascites carcinoma) by both the methods mentioned above, to see if this treatment would influence the survival time of the mice and the blood content of the tumour ascites.

The Significance of the Blood Content of the Ehrlich Ascites Carcinoma