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I-N the studv described in this paper, we have attempted to learn how the incidence of tumours elicited in mouse skin by initiating and promoting stimuli (reviewed by Salaman, 1958) is related, quantitatively, to the amount of carcinogenic hydrocarbon absorbed by the skin, rather than to the amount apphed. Methods have been devised (McCarter, 1956) to confine the apphed hydrocarbon to a measured area of the skin of an immobibzed mouse and to limit the amount absorbed bv hmiting the time that excess hydrocarbon remains on the skin. Some animals are kifed so that the amount of the hydrocarbon absorbed by the skin can be determined. Others are allowed to hve and are treated topicaRy with croton oil to produce tiimours. Using these techniques, it was possible to show (McCarter, Szerb and Thompson, 1956) that the niimber of tumours produced in the skin of a mouse varied directlv -a-ith the area of skin covered by the hydrocarbon, with the time aBowed for absorption and with the logarithm of the concentration of the solution apphed (9,10-dimethvl-1,2-benzanthmcene in fiquid paraflm). Subsequently (McCarter, 1958), an attempt was made to relate the tiimour incidence t-o the amount of hvdrocarbon (3,4-benzopyrene) that penetrated unit area of skin in a given time f.llowing the application of a solution of the substance in acetone. The present paper describes a siniflar, but more extensive investigation using 9,10-dimethvl1,12-benzanthrace,ne, hereafter called DMBA.

A Study of Dose and Effect in Initiation of Skin Tumours by a Carcinogenic Hydrocarbon