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cases however, times both of palliation and of survival had to be measured in months rather than years. We therefore considered the possibility that the limited benefits of hormonal surgery might be related to the advanced stage of the disease at the time of operation, and might be improved by earlier operation. We decided to put this hypothesis to the test by operating on a small number of patients with a bad prognosis as soon after the primary operation as practicable. The first patient was operated on in November 1954, and since that date there 1-iave been 10 further cases. Many years would have to pass before there could be positive evidence that the operation was of value, but evidence against the operation being of value could accumulate in a shorter time. Such evidence appears to be accumulating, and is reported in the present paper.

Early (Prophylactic) Oophorectomy and Adrenalectomy in Carcinoma of the Breast; An Interim Report