English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

HUSEBY AND BITTNER (1951) published a study of the development of spontaneous breast tumours in castrated male mice of the A strain bearing ovarian grafts. They found an incidence of 40 per cent developed breast tumours, whereas only 5 per cent had been found to occur in a small group of ovariectomised female mice bearing subcutaneous ovarian grafts (Huseby and Bittner, 1948). Four per cent of virgin and 80 per cent of breeding female mice of this strain develop breast cancer. Loeb, Blumenthal and Kirtz (1944) had also reported a greater frequency of breast tumours in castrate male mice bearing ovarian grafts than in normal females bearing such grafts. Their experiments were done with various strains, but over half were A strain. However, the early work of Murray (1928) suggested that in the dba strain approximately the same low frequency occurred in castrated males with subcutaneous ovaries as in virgin females of the same strain. The present study was undertaken to compare the incidence of chemicallyinduced breast tumours in castrated male and female mice of the IF strain bearing ovarian grafts. Unlike the A strain, the IF strain is free from the mammary tumour agent (Dmochowsky and Orr, 1949), but its breast tissue is extremely sensitive to the action of certain chemical carcinogens. Induction of breast tumours in males and females of this sensitive strain has recently been studied in some detail (Jull, 1954; Bonser, 1954; Marchant, 1958), but no direct comparison of the two sexes has previously been made in this manner.

The Induction of Breast Tumours by Methylcholanthrene in Castrated Male and Female Mice of the IF Strain Bearing Ovarian Grafts