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IN previous studies (Mutolo and Abrignani, 1957) it has been observed that mitochondria isolated from 256 Walker tumour cells are more susceptible to the action of trypsin than are those from normal rat liver. It was also found that the decrease of optical density of a mitochondrial suspension in the presence of anionic detergents was more marked with mitochondria derived from normal liver tissue than with mitochondria from tumour cells. This result suggested a structural-chemical difference between the proteins of the membrane of normal and tumour mitochondria. Recently, however, Cooper and Tapley (1957) have compared the response of the mitochondria from various normal tissues to several swelling agents and found considerable differences. These observations called for caution in the interpretation of our results and it seemed imperative to check their general validity with an extensive study of the mitochondria isolated from several normal tissues and organs and several strains of tumours. The results of such investigations are reported in the present paper and they seem to lend support to our previous conclusions.

The Effect of Anionic Detergents and Trypsin on Mitochondria of Normal and Tumour Tissues