English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

EPIDERMAL carcinogenesis in the mouse has been divided into two stages (Berenblum, 1954). In the first, the skin is prepared so that in the second a suitable non-carcinogenic or weakly carcinogenic agent is able to elicit a high incidence of epidermal tumours in the prepared skin. Most of the agents found able to prepare the skin in this way have been applied topically, but in three instances the agent was given by another route. 2-Acetylaminofluorene given by mouth (Ritchie and Saffiotti, 1955), 9,10-dimethyl-1,2-benzanthracene given orally, intraperitoneally or intravenously (Graffi, Scharsach and Heyer, 1955) and urethane given by mouth (Haran and Berenblum, 1956) have all been reported able to prepare mouse skin in this way. The present paper describes a fourth manner in which mouse skin can be prepared in this way by an agent which is not applied topically. Intraperitoneally administered urethane has been found adequate to prepare mouse skin so that subsequent topical applications of croton oil are able to elicit a higher incidence of papillomata than croton oil can elicit in unprepared skin.

Epidermal Carcinogenesis in the Mouse by Intraperitoneally Administered Urethane Followed by Repeated Applications of Croton Oil