English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

IN a previous communication (Cohen and Cohen, 1954b) it was noted that tumours arising from viable grafts of the C3H mammary carcinoma, which had been attenuated by sublethal doses of radiation immediately before implantation, were found, when subsequently irradiated in situ, to have a significantly increased radiosensitivity. The radiosensitization did not appear to be due to any permanent change in the tumour, or to any local reaction in the tumour bed, but could be explained only on the basis of a subliminal systemic resistance mechanism, possibly in the nature of a circulating iso-antibody arising in the host. If this postulate is correct, it might be possible to enhance the radio-sensitivity of an established non-attenuated isograft by inoculation of the host with a suitably attenuated second implant. The present investigation demonstrates that induced radiosensitization of an isogenic tumour in inbred mice is feasible, and may possibly point the way to more efficient therapy of autogenous growths. The procedure is complicated by additional variables not encountered when the radiation-attenuated homografts themselves are treated. The attenuation doses can vary widely, and may include a higher dosage range where the irradiated inocula no longer "take ". One may also choose almost any interval between implantation of the unmodified tumour and the inoculation of the irradiated fragment. Further, the time between the dates of implantation of the attenuated inoculum and of the treatment in situ of the established tumour may vary widely. The present experiment, therefore, is designed firstly to explore the possibility of radiosensitization of an unmodified transplanted C3H mammary adenocarcinoma by means of an attenuated tumour inoculum, and secondly to seek effective combinations of timing and dosage factors for this type of procedure.

british journal of cancer

Radiobiology of the C3H Mouse Mammary Carcinoma: Increased Radiosensitivity of the Tumour Induced by Inoculation of the Host with Radiation-Attenuated Isografts