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and Orr, 1953) have presented results of experiments on transference of various skin layers and the effects of trauma during chemical carcinogenesis. From these experiments the following main points have emerged: Pure epidermal or thin Thiersch grafts of carcinogen-treated skin transplanted to untreated body sites of the same mouse did not give rise to tumours. When such grafts were subsequently painted with croton oil, the number of papillomata which appeared was not significantly different from the number obtained by painting normal body skin with croton oil alone. Numerous tumours appeared on the original treated donor site. Thick Thiersch grafts and full-thickness grafts of carcinogen-treated skin yielded a small number of tumours after trans-plantation to sites in normal body skin. Large numbers of tumours appeared when a denuded carcinogen-treated area was left to resurface itself, or resurfaced with tail epithelium which had not received carcinogenic treatment. Reim-plantation of grafts into the site from which they were cut in carcinogen-treated skin gave a number of papillomata which later regressed, but the number of persistent tumours was not increased above that of control animals. The present experiments are further extensions of the above, and include some in which grafting procedul'es were carried out prior to carcinogen treatment. The standard treatment employed was as described in the previous reports, namely, once weekly applications of a drop of 0.3 per cent solution of 20-methyl-cholanthrene in acetone for 12 weeks. The animals used were adult white mice of mixed stock and both sexes. OPERATIVE METHODS. These have also been described in previous papers, grafting being done under aseptic conditions with nembutal anaesthesia. Grafts were bound in place by gauze impregnated with petroleum jelly wound firmly round the thorax of the mouse and covered with "Gypsona" plaster-impregnated bandage. The dressings were finally removed after 2 to 3 weeks.

A Further Investigation of the Rôle of Skin Components in Chemical Carcinogenesis