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IMMUNITY to transplanted tumours in animals has been extensively investigated although failure to control genetic factors rendered much of the earlier work of doubtful value. Following the criticisms of Woglom (1929), greater attention was paid to experimental design particularly with regard to the host-tumour relationship and in a number of studies, immunity has been produced against tumours which arose in, and grew progressively in inbred strains of animals (Hauschka, 1952; Stern, 1953). In a series of studies reported by Aptekman, Lewis and King (1946, 1949) and by Lewis, King, Aptekman and Seibert (1948), immunity to transplanted tumours in inbred rats was induced following destruction of growing tumours by injecting them with ethanol extracts of homologous tumour tissue and by pre-treating tumour-susceptible rats with the tumour extracts. The tumours used in these studies were induced in inbred strains of rats and were transplanted into animals of the same strains. In most cases, however, the tumours had been repeatedly sub-passaged and it was suggested by Hauschka (1952) that this repeated transplantation may have produced immunogenetic differences between tumour and host strain of animals which would favour a refractory state following tumour destruction. In the following experiments, the effect of tumour extracts on tumour growth has been studied using methylcholanthrene-irnduced tumours in inbred rats. Initially, these tumours had not been through many transplant generations so that any effect due to repeated tumour transplantation would be minimized. Experiments were also performed using tumours which had been sub-passaged through known numbers of generations so that any effect due to repeated tumour transplantation could be determined.

Immunity to Transplanted Tumour: The Effect of Tumour Extracts on the Growth of Homologous Tumours in Rats