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(1) An increase in pregnancy in mice and in rats (Kennaway and Kennaway, 1944; Kennaway and Tipler, 1947). (2) In mice, an increase following the injection (subcutaneous or intraperitoneal) of seven carcinogenic polycyclic hydrocarbons, of 1 : 2-benzanthracene and of stilboestrol, while 9: 10-dimethylanthracene (carcinogenic to skin), anthracene, phenanthrene, and naphthalene had no such effect (Kennaway, Kennaway and Warren, 1944). (3) 2-Acetamidofluorene when injected (subcutaneously and intraperitoneally) caused an increase in male, but not in female, CBA mice, and in black-and-white, and in Wistar rats, and an increase also when fed to Wistar rats. The 7-OH derivative had no such effect except for a very slight increase in black-and-white rats (Daff, Hoch-Ligeti, Kennaway and Tipler, 1948). (4) The fall in ascorbic acid content of the liver in mice on a vitamin-free diet is prevented by the addition of yeast, milk or methionine; riboflavin, below a certain dosage, is equally effectual (Kennaway and Daff, 1946). The action of some of these factors has now been tested in guinea-pigs, in which species the inability to synthesise ascorbic acid makes the metabolism of this compound similar to that in man. All amounts of ascorbic acid in tissues are stated below as ,ug. /g. wet weight. The effects of some factors upon the concentration of ascorbic acid in the liver in guinea-pigs, and in mice, are compared in Table I.

Carcinogenic Agents and the Metabolism of Ascorbic Acid in the Guinea-Pig