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THE work so far carried out on the liver catalase depressing action of tumours has been largely confined to rats and mice. Various attempts have been made to isolate the active agent resulting in semi-purified fractions active against liver catalase in vivo (Nakahara and Fukuoka, 1949, 1950; Greenfield and Meister, 1951). The Rous sarcoma of fowls is of general interest because it can be transmitted by a filterable agent. It seemed worth while to study the liver catalase system in chickens, with particular reference to any effects which may result from the presence of a Rous tumour, or the injection of homogenised Rous tissue. (See Adams, 1950, 1951a, 1951b for comparable work in mice.) If the chicken liver catalase system were found to be tumour-sensitive, it would be of immediate interest to see whether purified Rous virus carried the active agent. Some preliminary studies are detailed in the present paper, but it is not yet possible to answer the last question.

Some Studies on Liver Catalase in Embryonic and Immature Chickens and Mice