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IT has been noted in the past by various workers that the amount of infective virus obtainable from extracts of Rous No. 1 sarcomata varies from 0 to approximately 107 infective doses per gramme of tissue and is dependent on such factors as the rate of growth of the tumour, the age of the host bearing the tumour, and the age of the tumour itself (Carr, 1943, 1953; Duran-Reynals and Freire, 1953). Provided that the extracts are made from tumours of approximately the same age, the influence of antibody on virus yield can be kept within fairly constant limits and the effect of rate of growth and host age can be studied. So far, there have been no reports in the literature of a correlation between the actual quantities of virus material present in tumour extracts and the infectivity of such extracts. The experiments to be described were therefore designed to investigate any possible relationship between these two factors.

Relation between the Amount of Virus Material and Infectivity of Rous No. 1 Sarcomata