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ALTHOUGH attempts have been made to induce gastric adenocarcinomas in laboratory animals by parenteral administration of carcinogens, none has been successful (Klein and Palmer, 1941; Barrett, 1946; Hartwell, 1951). It occurred to Ray and Peters (1951, and unpublished data) that one might be able to subject the glandular mucosa of the stomach to a carcinogen by administering a suitable compound which would be selectively secreted by the gastric glands. Thus, it was reported that fluorene-2-azo-2', 4'-dihydroxybenzene (Compound III), a derivative of the carcinogen 2-aminofluorene, was found in the gastric juice of the rat following intraperitoneal injection (Ray and Peters, 1951). All the animals in the latter experiments had been operated on several hours prior to injection time, and the intestine in the region of the pylorus ligated to eliminate the possibility of back-flow into the stomach. In addition, each rat was injected with histamine. In the dog, which has been employed frequently for studies in gastric physiology, histamine is known to enhance the flow of gastric juice. However, Friedman (1943) reported that histamine did not stimulate secretion in the rat's stomach. In the present experiments the ability of the gastric mucosa to secrete Compound III was investigated in the rat as well as in the mouse and guinea-pig. The influence of histamine on gastric secretion and on blood volume in these species also was studied.

Gastric Secretion of Fluorene-2-Azo-2', 4'-Dihydroxybenzene in the Rat, Mouse, and Guinea-Pig