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BRONCHIOGENIC carcinoma, a comparative rarity a generation ago, is not only six times more commonly diagnosed than 25 years ago, but is considered by some authorities to be the most frequently encountered malignant tumor in males today. Graham (1950) has stated that only about 25 per cent of such cases are candidates for total pneumonectomy. Others claim that the overall cure rate by surgery, with or without accompanying x-irradiation, is only about 5 per cent. Apparently late diagnosis, due to paucity of symptoms at an early stage and inadequacy of diagnostic methods, are largely responsible for the number of cases which are not subject to present methods of treatment. Therefore any possible means of attack in this disease condition warrants careful appraisal and exploitation. It has been demonstrated by Meneely, Quarles and Curtis (1951) that when water-soluble materials tagged with radioactive isotopes are administered by tracheal route, the water is rapidly absorbed by the alveoli of the lungs. When radioactive metallic colloidal gold sols were administered under similar circumstances it was found that the fluid vehicle was absorbed, and the gold remained for many days in the lung parenchyma and did not gain access to the blood stream. In these latter experiments, aimed at not only the distribution of the gold colloid, but also at determining the tolerance of the animal to withstand irradiation of selected portions of the lung, large doses were administered at therapeutic levels. However, the gold colloid was drained very slowly by the regional lymphatics, it taking from 10 days to 2 weeks in order to attain concentrations sufficient to permit adequate radiation of these tissues which play an important part in the usual metastatic sequelae in bronchiogenic carcinoma. The gold isotopes Au198 and Au199 having half-lives of 2*7 and 3*3 days respectively would thus normally be unsuitable for therapeutic use in this disease, at least when used alone. Therefore other possible isotopes were considered for experimental use, and it was thought that Agll, with a half-life of 7*5 days, might offer possible advantages, especially since it meets most of the criteria for use as a therapeutic isotope (Hahn, 1951). Upon trial it was found that the colloids of metallic silver were rapidly transported to the regional lymphatics of the lung following intra-pulmonary administration. Unfortunately this isotope of silver is difficult to produce in the

british journal of cancer

Radioactive Metallic Gold Colloids Coated with Silver and their Distribution in the Lung and its Lymphatics following Intra-Pulmonary Administration: Therapeutic Implications in Primary Lung and Bronchiogenic Tumors