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IT has been shown that following the inoculation of neoplastic tissues or of blood from one pure strain of mice into another. a variety of different tvpes of antibody might be formed (Gorer, 1942, 1947). Confining our attention to the reactions obtained with the ervthrocytes of the donor strain, it was found that three different types of antibodv could be demonstrated: the ordinary agglutinin, an agglutinin that was active in high concentrations of normal mouse serum, and ' blocking" antibodies. The last could only be demonstrated by their inhibiting action with the ordinary agglutinins. The albumin technique of Diamond and Denton (1945) was not applicable, since mouse cells are lysed by albumin. Attempts to produce a Coombs serum (Coombs. Mourant and Race. 1945) by inoculating rabbits with normal mouse plasma were not successful. This is not without interest, since it may indicate that the blocking antibody globulin of mice is absent from normal serum, or present in too low a concentration to elicit antibodies in the rabbit. Such a state of affairs is not without precedence. Thus van den Ende (1940) showed that guinea-pigs inoculated with normal rabbit serum would not give precipitation with purified anti-pneumococcal antibodv. Similarly physico-chemical studies in horse sera show the presence of a new type of molecule following immunization (Green, McKalk, Kapnick and Fahey, 1939; van der Scheer, Wyckoff and Clarke, 1941). WAhilst these questions will have to be cleared up, it was decided to attempt other methods first. It was thought that some animal sera might enhance agglutination, and a few experiments were performed whilst the author was at the Roscoe Jackson Laboratory with rabbit and horse sera. In both these cases it was obvious that the absorption of natural anti-mouse agglutinins from the undiluted sera would be a formidable task. The work of Waaler (1939), Wiener (1944, 1945) and Boorman and Dodd (1947) suggested the value of human serum in enhancing agglutination, and the results obtained thereby are reported below.

Studies in Antibody Response of Mice to Tumour Inoculation