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EVIDENCE offered by Calcutt (1949) showed that 3:4-benzpyrene is effe'tive in inducing the oxidation of the -SH groups of a variety of compounds, the benzpyrene itself also undergoing oxidation during this process. On the basis of physical properties and fluorescence spectra it was suggested that the benzpyrene derivatives obtained in this fashion were, comparable to those obtained as a result of the metabohsm of the hydrocarbon by mice. This suggestion is important in view of Crabtree's (1947) conclusions as to the involvement of -SH groups in the carcinogenic process, and also in relation to Powell and Calcutt's (1949) conclusion that the availability of sulphydryl influences the metabohsm of benzpyrene. The present paper reports an attempt at the solution of the problem of the mechanism of the oxidative processes undergone by benzpyrene in the, presence of autoxidizing thiols. 'Studies by Weigert and Mottram (1946a, 1946b) showed that the initial step in the metabolism of benzpyrene is conversion to either 8:9-dihydro 8:OR, -9.OH benzpyrene (BpX,) or 8:9-dihydro 8:OR, -9OR2 benzpyrene (BpX2), R, and R2 being unidentified radicals. At the same time it was shown that these compounds

Mechanism of Oxidation of 3:4-Benzpyrene in the Presence of Autoxidizing Thiols