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a strong belief that cancer occurring in the very old may be so slow in growth as not to limit the " natural "' duiration of life. in anattempt to find out to what extent these impressions are justified we shall give (a) The opinions put forward in some relevant articles in the literature. (b) The results of a study of the niicroscopic structure of some tumours in patients of different age groups. Most diseases have an age period of maximum frequency and probably alsoan age period of maximum intensity and virulence. It does not follow, of course, that these age periods coincide, although it wouldbe reasonable to expect that the a-ae -aroup in which the disease occurred most frequently was also that in which the disease occurred most virulently. Cancer is predominantly a disease of senescence, and if one had, a priori, to foretell its malignancy, one would expect.its virulence to be most intense at higher age periods. On the other hand, the cancer cell seems to differ from the phys'iological cell only in its 'greatly increased growth potential. It seems otherwise to share, perhaps disproportionately, in the metabolic turnover of the body. One might expect, since the nutritive efficiency -is presumptively greater in the young, that the cancer cells would grow and divide rather faster in the young. In actual fact the age incidence of disease by frequencv and by virulence has not much law or reason and is just an empirical fact. We have little doubt that in so far as the belief in increased virulence of cancer at young ages is not based on clinical experience it is based on the assumption that physiological tissue gro'wth and activity is much greater in the young, as, for example, in the muscular hyperplasia following fun'ctional over-use.

The Malignancy of Cancer at Different Ages: A Histological Study