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IN a review devoted to the discussion of colchicine as a possible chemotherapeutic agent for cancer (Ludford, 1945), attention was directed to the dual action of this drug on tumours. It is the most potent of mitotic poisons, and as. the action of these substances is greatest where cell division is most frequent, colchicine has a relatively greater effect upon rapidly growing neoplasms than upon most tissues of adult organisms. Furthermore, since endothelial cels of growing capillaries are particularly sensitive to its toxic action, it induces extensive haemorrhage in the soft highly cellular rapidly growing types of tumours. Evidence was adduced that regression of malignant growth produced by colchicine is mainly the result of this vascular damage. Considerable variation in the response of different tumours to treatment with this drug has been reported, and the present paper represents an attempt to elucidate the factors which are responsible for such differences.

Factors Determining the Action of Colchicine on Tumour Growth