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KCNQ1 and KCNE1 form a complex in human ventricular cardiomyocytes, which are important in maintaining a normal heart rhythm. In the present study we investigated the effects of a homologous series of 1-alkanols on KCNQ1/KCNE1 channels expressed in Xenopus oocytes.

The residue I257 at S4–S5 linker in KCNQ1 determines KCNQ1/KCNE1 channel sensitivity to 1-alkanols