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High-resolution microendoscopy (HRME) is a low-cost, "optical biopsy" technology that allows for subcellular imaging. The purpose of this study was to determine the in vivo diagnostic accuracy of the HRME for the differentiation of neoplastic from non-neoplastic colorectal polyps and compare it to that of high-definition white-light endoscopy (WLE) with histopathology as the gold standard.

In Vivo Diagnostic Accuracy of High-Resolution Microendoscopy in Differentiating Neoplastic from Non-Neoplastic Colorectal Polyps: A Prospective Study