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To the Editor: The risk of malignancy in Crohn's disease (CD) has been well described. Moreover, immunomodulators, such as azathioprine (AZA) and 6-mercaptopurine (6-MP), and biological agents, such as infliximab and adalimumab, may promote carcinogenesis (1,2,3).

the american journal of gastroenterology

Splenic Littoral Cell Hemangioendothelioma in a Patient With Crohn's Disease Previously Treated With Immunomodulators and Anti-TNF Agents: A Rare Tumor Linked to Deep Immunosuppression