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Dendritic cells (DCs) as antigen presenting cells can stimulate naive CD4(+) T cells and initiate the primary immune response which controls Th1/Th2 development. It has been suggested that DCs derived from different tissues have distinct properties. We investigated whether DCs from mesenteric lymph nodes (MLN), Peyer's patches (PP) and spleen (SPL) could induce different responses of naive CD4(+) T cells to varying doses of antigen by using a co-culture system of DCs and T cells. DCs from each tissue induced IL-4 secretion from naive CD4(+)T cells in the presence of low dose antigenic peptide, and induced IFN-gamma production at high doses of antigen. When purified CD11c(+)/B220(-) DCs were used, MLN-derived DCs induced a higher amount of IFN-gamma secretion from naive CD4(+) T cells, compared with SPL-derived DCs. We could not detect large differences in the expressions of costimulatory molecules on the surface of these two populations of DCs. On the other hand, we found that large amounts of IL-12 were secreted from MLN DCs in an antigen dose-dependent fashion. In conclusion, DCs from SPL, MLN and PP can induce the production of both IL-4 and IFN-gamma from naive CD4(+) T cells, depending on antigen dose. MLN-derived CD11c(+)/B220(-) DCs induce higher IFN-gamma production from naive CD4(+) T cells than SPL-derived DCs, through efficient IL-12 secretion.

cytotechnology

Dendritic Cells from Spleen, Mesenteric Lymph Node and Peyer's Patch Can Induce the Production of Both IL-4 and IFN-γ from Primary Cultures of Naive CD4+ T Cells in a Dose-Dependent Manner