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A new antiepileptic ceramide mixture 1 was isolated from the Red Sea sponge Negombata corticata. The structures of the metabolites were determined by extensive spectroscopic analysis. The anticonvulsant activity of 1 was measured in vivo using the pentylenetetrazole-induced seizure model. This finding has important implications for biological studies with this class of compounds.

Antiepileptic Ceramides from the Red Sea Sponge Negombata corticata