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A new scalarane-type pentacyclic sesterterpene, sesterstatin 6 (6), was isolated in 8.3 x 10(-7)% yield from the Republic of Maldives marine sponge Hyrtios erecta. The structure was elucidated by analyses of HRMS and high-field 2-D NMR spectra. Sesterstatin 6 showed significant cancer cell growth inhibition against murine P388 lymphocytic leukemia and a series of human tumor cell lines (ED50 0.17 microg/mL, GI50 1.8-8.9 x 10(-1) microg/mL) and proved to be the most inhibitory of the series.

Antineoplastic Agents. 542. Isolation and Structure of Sesterstatin 6 from the Indian Ocean Sponge Hyrtios erecta