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A facile methodology to prepare water-dispersible nanogels based on pentafluorophenyl acrylate and polyethylene glycol methacrylate random copolymer and diamine cross-linkers has been developed. Cross-linking reaction was characterized by FTIR and 19 F NMR. We show that those nanogels : ( i ) are water-dispersible; ( ii ) can conveniently encapsulate lipophilic guest molecules; ( iii ) can be prepared with different nanosizes; ( iv ) are engineered to allow for surface decoration with additional functional groups.

Facile Preparation of Nanogels Using Activated Ester Containing Polymers