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The first realization of a biomolecular OR gate function with double-sigmoidresponse (sigmoid in both inputs) is reported. Two chemical inputs activate theenzymatic gate processes resulting in the output signal: chromogen oxidation,which occurs when either one of the inputs or both are present (correspondingto the OR binary function), and can be optically detected. High-quality gatefunctioning in handling of sources of noise is enabled by "filtering" involvingpH control with an added buffer. The resulting gate response is sigmoid in bothinputs when proper system parameters are chosen, and the gate properties aretheoretically analyzed within a model devised to evaluate its noise-handlingproperties.

Enzyme-Based Logic: OR Gate with Double-Sigmoid Filter Response