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Catalytic asymmetric synthesis of neolignan natural products (-)-epi-conocarpan and (+)-conocarpan has been achieved by exploiting an enantio- and diastereoselective intramolecular C-H insertion reaction to construct a cis-2-aryl-2,3-dihydrobenzofuran ring system as a key step. The C-H insertion reaction of 5-bromoaryldiazoacetate catalyzed by Rh(2)(S-PTTEA)(4), a new dirhodium(II) carboxylate complex that incorporates N-phthaloyl-(S)-triethylalaninate as chiral bridging ligands, provided 2-aryl-5-bromo-3-methoxycarbonyl-2,3-dihydrobenzofuran with exceptionally high diastereoselectivity (cis/trans = 97:3) and high enantioselectivity for the cis isomer (84% ee).

journal of organic chemistry

Asymmetric Synthesis of Neolignans (−)-<i>epi</i>-Conocarpan and (+)-Conocarpan via Rh(II)-Catalyzed C−H Insertion Process and Revision of the Absolute Configuration of (−)-<i>epi</i>-Conocarpan

Asymmetric Synthesis of Neolignans (−)-epi-Conocarpan and (+)-Conocarpan via Rh(II)-Catalyzed C−H Insertion Process and Revision of the Absolute Configuration of (−)-epi-Conocarpan